Complicaciones quirúrgicas del linfoma con compromiso gastrointestinal

Palabras clave: limfoma, tracto gastrointestinal, neoplasias gastrointestinales, obstrucción intestinal, perforación intestinal, intususcepción

Resumen

Introducción. El linfoma puede afectar el tracto gastrointestinal de manera primaria o secundaria, y representa hasta el 2 % de todas las neoplasias malignas del intestino delgado y colon. El tracto gastrointestinal es la ubicación extraganglionar primaria más común en el linfoma no Hodgkin.

Métodos. Se realizó una búsqueda de la literatura en las principales bases de datos académicas, con revisión de textos publicados sobre el tema en los últimos 5 años.

Discusión. La presentación clínica del linfoma con compromiso gastrointestinal es inespecífica y, hasta en la mitad de los pacientes, se puede presentar de manera inicial con complicaciones que requieran manejo quirúrgico. Entre las principales se encuentran la perforación intestinal, el sangrado digestivo y la obstrucción intestinal.

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Biografía del autor/a

Juliana Lucia Molina-Valencia, Universidad de Antioquia, Medellín, Colombia.

Médica, residente de Cirugía General, departamento de Cirugía General, Universidad de Antioquia, Medellín, Colombia.

Carlos Andrés Delgado-López, Hospital Pablo Tobón Uribe, Medellín, Colombia.

Médico, especialista en Cirugía General, Hospital Pablo Tobón Uribe, Medellín, Colombia.

Referencias

Shirwaikar TA, Schwartz M, Quigley E. Gastrointestinal lymphoma: the new mimic. BMJ Open Gastro. 2019;6:e000320. https://doi.org/10.1136/bmjgast-2019-000320

Hustings N, Feyaerts F. Large B-cell Lymphoma of the Jejunum. J Belg Soc Radiol. 2019;103:41. https://doi.org/10.5334/jbsr.1826

Kohri M, Tsukasaki K, Akuzawa Y, Tanae K, Takahashi N, Saeki T, et al. Peripheral T-cell lymphoma with gastrointestinal involvement and indolent T-lymphoproliferative disorders of the gastrointestinal tract. Leukemia Research. 2020;91:106336. https://doi.org/10.1016/j.leukres.2020.106336

Matysiak-Budnik T, Fabiani B, Hennequin C, Thieblemont C, Malamut G, Cadiot G, et al. Gastrointestinal lymphomas: French Intergroup clinical practice recommendations for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFH). Dig Liver Dis. 2018;50:124-131. https://doi.org/10.1016/j.dld.2017.12.006

Aoki T, Yamada A, Takahashi M, Niikura R, Toyama K, Ushiku T, et al. Development and internal validation of a risk scoring system for gastrointestinal events requiring surgery in gastrointestinal lymphoma patients. J Gastroenterol Hepatol. 2019;34:693-9. https://doi.org/10.1111/jgh.14452

Lightner AL, Shannon E, Gibbons MM, Russell MM. Primary gastrointestinal non-Hodgkin’s lymphoma of the small and large intestines: A systematic review. J Gastrointest Surg. 2016;20:827-39. https://doi.org/10.1007/s11605-015-3052-4

Corti M, Boschi A, Portillo Á, Méndez N, Campitelli A, Narbaitz M. Invaginación intestinal como forma de presentación de linfoma no Hodgkin primario de colon en un paciente VIH positivo. Rev Esp Enferm Dig. 2016;108:750-3. https://doi.org/10.17235/reed.2016.3965/2015

Facundo-Navia H, Manrique-Acevedo ME. Linfoma primario del intestino delgado: reporte de un caso y revisión de la literatura. Rev Colomb Gastroenterol. 2017;32:65- 71. https://doi.org/10.22516/25007440.132

Wang Y, Li Y, Meng X, Duan X, Wang M, Chen W, et al. Epstein-Barr virus-associated T-cell lymphoproliferative disorder presenting as chronic diarrhea and intestinal bleeding: a case report. Front Immunol. 2018;9:2583. https://doi.org/10.3389/fimmu.2018.02583

Rehaman SA, Ramachandra CS, Jackaya RP. Primary gastro intestinal lymphoma presenting as perforation peritonitis. J Clin Diagn Res. 2016;10:PD22-4. https://doi.org/10.7860/JCDR/2016/15462.7483

Iida T, Nozawa H, Sonoda H, Toyama K, Kawai K, Hata K, et al. Upfront surgery for small intestinal non-Hodgkin’s lymphoma. Anticancer Res. 2020;40:2373-7. https://doi.org/10.21873/anticanres.14206

Wang YG, Zhao LY, Liu CQ, Pan SC, Chen XL, Liu K, et al. Clinical characteristics and prognostic factors of primary gastric lymphoma: A retrospective study with 165 cases. Medicine. 2016;95:e4250. https://doi.org/10.1097/MD.0000000000004250

Sokhandon F, Al-Katib S, Bahoura L, Copelan A, George D, Scola D. Multidetector CT enterography of focal small bowel lesions: a radiological-pathological correlation. Abdom Radiol. 2017;42:1319-41. https://doi.org/10.1007/s00261-016-1015-1

Inada R, Fukata N, Ito T, Hamada M. A case of aneurysmal lymphoma of the small intestine. Jpn J Clin Oncol. 2016;46:288-9. https://doi.org/10.1093/jjco/hyw019

Isayama C, Takeuchi N, Takada M, Nishida Y, Nomura Y, Iida M, Otsuka A. Primary T-cell lymphoma with small intestinal perforation: A case report. J Med Cases. 2016;7:539-42. https://doi.org/10.14740/jmc2690w

Chin CK, Tsang E, Mediwake H, Khair W, Biccler J, Hapgood G, et al. Frequency of bowel perforation and impact of bowel rest in aggressive non-Hodgkin lymphoma with gastrointestinal involvement. Br J Haematol. 2019;184:826-8. https://doi.org/10.1111/bjh.15173

Imataki O, Shiroshita K, Uchida S, Kida J, Akamoto S, Uemura M. Perforation in an intestinal malignant lymphoma case. BMC Res Notes. 2016;9:308. https://doi.org/10.1186/s13104-016-2111-6

Karadeli E, Erbay G, Parlakgumus A, Yabanoglu H. Abdominal CT findings in patients with primary lymphoma causing small bowel obstruction. J Coll Physicians Surg Pak. 2017;27:711-713. https://doi.org/10.1594/ecr2017/C-1229

Wong YJ, Lum HM, Fook-Chong S, Lim ST, Salazar E. Do total parenteral nutrition and bowel rest reduce the risk for perforation in patients with gastrointestinal tract lymphoma receiving chemotherapy? Nutrition. 2019;67-68:110515. https://doi.org/10.1016/j.nut.2019.03.023

Lu YH, Chang ST, Yang SF, Weng SF, Huang WT, Hsieh PP, et al. Primary intestinal diffuse large B-cell lymphoma in Taiwan showed a relative higher rate of perforation and EBV association. Appl Immunohistochem Mol Morphol 2015;24:1–9. https://doi.org/10.1097/PAI.0000000000000226

Tatar C, Yavas M, Akkus O, Tapkan B, Batikan OK, Bayrak S, Arikan S. Intestinal perforation that developed after chemotherapy in a patient diagnosed with non-Hodgkin lymphoma: A case report and review of literature. Int J Surg Case Rep. 2017;39:321-3. https://doi.org/10.1016/j.ijscr.2017.08.058

Abbott S, Nikolousis E, Badger I. Intestinal lymphoma--a review of the management of emergency presentations to the general surgeon. Int J Colorectal Dis. 2015;30:151-7. https://doi.org/10.1007/s00384-014-2061-1

Singh A, Prabhakar G. Traumatic rupture of jejunal Burkitt’s lymphoma with intestinal transection. J Indian Assoc Pediatr Surg. 2019;24:61-2. https://doi.org/10.4103/jiaps.JIAPS_67_18

Sudworth O, Hameed A. Delayed diagnosis of a high-grade B-cell non-Hodgkin’s lymphoma presenting as an obstructing rectal mass. BMJ Case Rep. 2015;2015:bcr2015213146. https://doi.org/10.1136/bcr-2015-213146

Nehme F, Alderson J, Nassif I. Small bowel obstruction secondary to ileal mucosa-associated lymphoid tissue lymphoma. J Gastrointest Cancer. 2018;49:207-10. https://doi.org/10.1007/s12029-016-9882-9

Zaarour M, Busack C, Munker R. Obstructing duodenal diffuse large B-cell lymphoma with peritoneal lymphomatosis with exceptional response to R-CHOP. Cureus. 2019;11:e4621. https://doi.org/10.7759/cureus.4621

Leshchinskiy S, Ali N, D’Agostino R. The small bowel “aneurysm”. Abdom Radiol. 2018;43:3503-4. https://doi.org/10.1007/s00261-018-1605-1

Waisberg J, Anderi ADV, Cardoso PAS, Borducchi JHM, Germini DE, Franco MIF, et al. Extensive colorectal lymphomatous polyposis complicated by acute intestinal obstruction: a case report. J Med Case Rep. 2017;11:190. https://doi.org/10.1186/s13256-017-1340-1

Yang TW, Lin YY, Tsuei YW, Chen YL, Huang CY, Hsu SD. Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. World J Gastroenterol. 2016;22:4781-5. https://doi.org/10.3748/wjg.v22.i19.4781

Al-Radaideh AM, Omari HZ, Bani-Hani KE. Adult intussusception: A 14-year retrospective study of clinical assessment and computed tomography diagnosis. Acta Gastroenterol Belg. 2018;81:367-72.

İflazoğlu N, Mengeloğlu A, Korkmaz NS, Karaalioğlu B, Yülüklü M. Primary small bowel lymphoma presenting as invagination. Turk J Surg. 2018;34:331-3. https://doi.org/10.5152/turkjsurg.2017.3115

Valentini V, Buquicchio GL, Galluzzo M, Ianniello S, Di Grezia G, Ambrosio R, et al. Intussusception in adults: The role of MDCT in the identification of the site and cause of obstruction. Gastroenterol Res Pract. 2016;(11):5623718. https://doi.org/10.1155/2016/5623718

Negoi I, Paun S, Hostiuc S, Stoica B, Tanase I, Negoi RI, Beuran M. Most small bowel cancers are revealed by a complication. Einstein (Sao Paulo). 2015;13:500-5. https://doi.org/10.1590/S1679-45082015AO3380

El-Sergany A, Darwish A, Mehta P, Mahmoud A. Community teaching hospital surgical experience with adult intussusception: Study of nine cases and literature review. Int J Surg Case Rep. 2015;12:26-30. https://doi.org/10.1016/j.ijscr.2015.03.032

Kim MS, Park JH, Kim JY, Lim SN, Lee J. Upper gastrointestinal bleeding caused by direct invasion of diffuse large B-cell lymphoma into the stomach in a patient with HIV infection: A case report. Medicine (Baltimore). 2019;98:e16363. https://doi.org/10.1097/MD.0000000000016363

Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, et al. Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP. Cancer Med. 2019;8:982–9. https://doi.org/10.1002/cam4.1982

Juárez-Salcedo LM, Sokol L, Chavez JC, Dalia S. Primary gastric lymphoma, epidemiology, clinical diagnosis, and treatment. Cancer Control. 2018;25: 10732 74818778256. https://doi.org/10.1177/1073274818778256

Publicado
2021-04-14
Cómo citar
(1)
Molina-Valencia, J. L.; Delgado-López, C. A. Complicaciones Quirúrgicas Del Linfoma Con Compromiso Gastrointestinal. Rev Colomb Cir 2021, 36, 514-519.
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