Inestabilidad microsatelital y cáncer gástrico

Palabras clave: cáncer, gástrico, inestabilidad microsatelital, inmunoterapia, tratamiento

Resumen

La inestabilidad microsatelital es causada por una alteración de los sistemas de reparación de apareamiento
incorrecto, que puede afectar los microsatélites dentro de todo el genoma humano, produciendo errores en su replicación. Los estudios publicados, principalmente en la literatura inglesa, han encontrado que algunos tumores, como los gástricos, pueden expresar inestabilidad microsatelital.
En la siguiente revisión de tema, se presenta una descripción de los sistemas de reparación de apareamientos incorrectos y su relación con la presencia de inestabilidad microsatelital en los tumores gástricos, así como su posible utilidad clínica, como factor asociado en la respuesta al tratamiento con inmunoterapia en los pacientes con dicha patología.

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Biografía del autor/a

Gabriela Negrete-Tobar, Pontificia Universidad Javeriana, Bogotá D.C., Colombia

Estudiante de medicina, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Alejandro González-Motta, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá D.C., Colombia

Médico, especialista en Oncología y Radioterapia, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá, D.C., Colombia.

Oscar Alberto Messa-Botero, Pontificia Universidad Javeriana, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá DC, Colombia.

Médico, especialista en Patología oncológica; profesor asistente, Facultad de Medicina, Pontificia Universidad Javeriana, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá, D.C., Colombia.

Juan Carlos Galvis, Pontificia Universidad Javeriana, Centro Javeriao de Oncología; Hospital Universitario San Ignacio, Bogotá DC, Colombia

Médico, especialista en Oncología y Radioterapia, profesor ad honorem, Facultad de Medicina, Pontificia Universidad Javeriana, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá, D.C., Colombia.

Isabella Garciandía-Rozo, Pontificia Universidad Javeriana, Bogotá D.C., Colombia

Estudiante de medicina, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Juan Sebastián Álvarez-Martínez, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia

Estudiante de medicina, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Juliana Pineda-Ortega, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia

Estudiante de medicina, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Natalia Londoño de Vivero, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia

Estudiante de medicina, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Ricardo Bruges-Maya, Pontificia Universidad Javeriana, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá DC, Colombia

Médico, especialista en Oncología clínica; profesor asistente, Facultad de Medicina, Pontificia Universidad Javeriana, Centro Javeriano de Oncología; Hospital Universitario San Ignacio, Bogotá, D.C., Colombia.

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Publicado
2021-01-07
Cómo citar
1.
Negrete-Tobar G, González-Motta A, Messa-Botero OA, Galvis JC, Garciandía Rozo I, Álvarez Martínez JS, Pineda Ortega J, Londoño de Vivero N, Bruges Maya R. Inestabilidad microsatelital y cáncer gástrico. Rev Colomb Cir [Internet]. 7 de enero de 2021 [citado 17 de enero de 2021];36(1):120-31. Disponible en: https://www.revistacirugia.org/index.php/cirugia/article/view/658
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Artículo de Revisión