Tumor fibroso solitario del hígado: revisión del conocimiento actual
DOI:
https://doi.org/10.30944/20117582.370Palabras clave:
hígado, células del estroma mesenquimatoso, neoplasias hepáticas, tumor fibroso solitario, hemangiopericitoma, hepatectomíaResumen
El tumor fibroso solitario del hígado es infrecuente. Hasta la fecha, se han reportado menos de 50 casos en la literatura científica inglesa, la mayoría de los cuales se comportaron como tumores benignos. El objetivo del presente artículo es actualizar el conocimiento sobre este tumor porque, debido a su rareza, la presentación clínica, el estudio, el tratamiento y el pronóstico no son bien conocidos. Habitualmente, no produce sintomatología o es inespecífica y su comportamiento a largo plazo es incierto; no obstante, en algunos casos, se comporta agresivamente como un sarcoma de mal pronóstico. Actualmente, solo el tratamiento quirúrgico puede ofrecer una oportunidad terapéutica para estos pacientes. Debido a la falta de conocimiento sobre el comportamiento a largo plazo de estos tumores supuestamente benignos y a la falta de tratamiento médico específico, se sugiere el seguimiento metódico a largo plazo para garantizar la supervivencia de los pacientes operados por un tumor fibroso solitario del hígado.
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Referencias bibliográficas
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https://doi.org/10.1016/0046-8177(95)90147-7
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https://doi.org/10.1007/s00534-007-1210-0
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https://doi.org/10.3748/wjg.v19.i21.3354
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https://doi.org/10.1007/s00534-005-0993-0
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https://doi.org/10.1016/j.ijsu.2007.10.004
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https://doi.org/10.1186/1477-7819-9-37
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https://doi.org/10.1186/1746-1596-8-195
17. Korkolis DP, Apostolaki K, Aggeli C, Plataniotis G, Gontikakis E, Volanaki D, et al. Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report. World J Gastroenterol. 2008;14:6261-4.
https://doi.org/10.3748/wjg.14.6261
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https://doi.org/10.1007/s00423-008-0329-z
19. Chithriki M, Jaibaji M, Vandermolen R. Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. Am Surg. 2004;70:291-3.
20. Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, de Manzoni G, Laterza E, et al. Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia. J Hepatobiliary Pancreat Surg. 1998;5:212-6.
https://doi.org/10.1007/s005340050036
21. Anderson N, Lokich JJ. Mesenchymal tumors associated with hypoglycemia. Cancer. 1979;44:785-90.
https://doi.org/10.1002/1097-0142(197908)44:2<785::AID-CNCR2820440253>3.0.CO;2-S
22. Shetty MR, Boghossian HM, Duffell D, Freel R, González JC. Tumor-induced hypoglycemia. Cancer. 1982;49:1920-3.
https://doi.org/10.1002/1097-0142(19820501)49:9<1920::AID-CNCR2820490927>3.0.CO;2-M
23. Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, et al. Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci. 2000;45:168-74.
https://doi.org/10.1023/A:1005438116772
24. Pen L, Liu Y, Ai Y, Liu Z, He Y, Liu Q. Skull base metastases from a malignant solitary fibrous tumor of the liver: A case report and literature review. Diagnostic Pathol. 2011;6:127.
https://doi.org/10.1186/1746-1596-6-127
25. Fuksbrumer MS, Klimstra D, Panicek DM. Solitary fibrous tumor of the liver: Imaging findings. Am J Radiol. 2000;175:1683-7.
https://doi.org/10.2214/ajr.175.6.1751683
26. Moser T, Nogueira TS, Neuville A, Riehm S, Averous G, Weber JC, et al. Delayed enhancement pattern in a localized fibrous tumor of the liver. Am J Radiol. 2005;184:1578-80.
https://doi.org/10.2214/ajr.184.5.01841578
27. Taboada-Rodríguez V, Zueco-Zueco C, Sobrido-San Pedro C, Martínez-Vicente C. Tumor fibroso solitario hepático: hallazgos radiológicos y revisión de la bibliografía. Radiología. 2010;52:67-70.
https://doi.org/10.1016/j.rx.2009.09.008
28. Soussan M, Felden A, Cyrta J, Morere JF, Douard R, Wind P. Solitary fibrous tumor of the liver. Radiology. 2013;269:304-8.
https://doi.org/10.1148/radiol.13121315
29. Nath DS, Rutzick AD, Sielaff TD. Solitary fibrous tumor of the liver. Am J Radiol. 2006;187:W187-90.
https://doi.org/10.2214/AJR.05.0294
30. Ginat DT, Bokhari A, Bhatt S, Dogra V. Imaging features of solitary fibrous tumors. Am J Radiol. 2011;196:487-95.
https://doi.org/10.2214/AJR.10.4948
31. Weimann A, Ringe B, Klempnauer J, Lamesch P, Gratz KF, Prokop M, et al. Benign liver tumors: Differential diagnosis and indications for surgery. World J Surg. 1997;21:983-91.
https://doi.org/10.1007/s002689900337
32. Terkivatan T, de Wilt JH, de Man RA, van Rijn RR, Zondervan PE, Tilanus HW, et al. Indications and long-term outcome of treatment for benign hepatic tumors. Arch Surg. 2001;136:1033-8.
https://doi.org/10.1001/archsurg.136.9.1033
33. Ibrahim S, Chen CL, Wang SH, Lin CC, Yang CH, Yong CC, et al. Liver resection for benign liver tumors: Indications and outcome. Am J Surg. 2007;193:5-9.
https://doi.org/10.1016/j.amjsurg.2006.04.017
34. Clarke DL, Currie EJ, Madhavan KK, Parks RW, Garden OJ. Hepatic resection for benign non-cystic liver lesions. HPB. 2004;6:115-9.
https://doi.org/10.1080/13651820410026326
35. Novais P, Robles-Medranda C, Pannain VL, Barbosa D, Biccas B, Fogaca H. Solitary fibrous liver tumor: Is surgical approach the best option? J Gastrointest Liver Dis. 2010;19:81-4.
36. Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, et al. Management of primary liver sarcomas. Cancer. 2007;109:1391-6.
https://doi.org/10.1002/cncr.22530
37. Ali SZ, Hoon V, Hoda S, Heelan R, Zakowski MF. Solitary fibrous tumor: A cytologic-histologic study with clinical, radiologic, and immunohistochemical correlations. Cancer. 1997;81:116-21.
https://doi.org/10.1002/(SICI)1097-0142(19970425)81:2<116::AID-CNCR5>3.0.CO;2-Q
38. Gengler C, Guillou L. Solitary fibrous tumor and hemangiopericytoma: Evolution of a concept. Histopathology. 2006;48:63- 74.
https://doi.org/10.1111/j.1365-2559.2005.02290.x
39. Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S, Hirose T, Sano T. Frequent expression of bcl-2 protein in solitary fibrous tumors. Jpn J Clin Oncol. 1998;28:86-91.
https://doi.org/10.1093/jjco/28.2.86
40. Torabi A, Lele SM, DiMaio D, Pinnt JC, Hess MM, Nelson M, et al. Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor. Cancer Genet Cytogenet. 2008;181:60-4.
https://doi.org/10.1016/j.cancergencyto.2007.11.005
41. Levard A, Derbel O, Méeus P, Ranchere D, Ray-Coquard I, Blay JY, et al. Outcome of patients with advanced solitary fibrous tumors: The Center Léon Bérard experience. BMC Cancer. 2013;13:109.
https://doi.org/10.1186/1471-2407-13-109
42. Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, et al. Sunitinib malate and figitumumab in solitary fibrous tumor: Patterns and molecular bases of tumor response. Mol Cancer Ther. 2010;9:1286-97.
https://doi.org/10.1158/1535-7163.MCT-09-1205
43. Stacchiotti S, Negri T, Libertini M, Palassini E, Marrari A, De Troia B, et al. Sunitinib malate in solitary fibrous tumor (SFT). Ann Oncol. 2012;23:3171-9.
https://doi.org/10.1093/annonc/mds143
44. Mosquera JM, Fletcher CD. Expanding the spectrum of malignant progression in solitary fibrous tumors. Am J Surg Pathol. 2009;33:1314-21.
https://doi.org/10.1097/PAS.0b013e3181a6cd33
https://doi.org/10.1016/j.athoracsur.2009.07.026
2. Langman G. Solitary fibrous tumor: A pathological enigma and clinical dilemma. J Thorac Dis. 2011;3:86-7.
3. Hanau CA, Miettinen M. Solitary fibrous tumor: Histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol. 1995;26:440- 9.
https://doi.org/10.1016/0046-8177(95)90147-7
4. Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer. 2002;94:1057-68.
https://doi.org/10.1002/cncr.10328
5. Kunieda K, Tanaka Y, Nagao N, Yamaguchi K, Sano J, Osada S, et al. Large solitary fibrous tumor of the retroperitoneum: Report of a case. Surg Today. 2004;34:90-3.
https://doi.org/10.1007/s00595-003-2632-1
6. Kanthan R, Torkian B. Recurrent solitary fibrous tumor of the pleura with malignant transformation. Arch Pathol Lab Med. 2004;128:460-2.
7. Chan G, Horton PJ, Thyssen S, Lamarche M, Nahal A, Hill DJ, et al. Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. J Hepatobiliary Pancreat Surg. 2007;14:595-9.
https://doi.org/10.1007/s00534-007-1210-0
8. Jakob M, Schneider M, Hoeller I, Laffer U, Kaderli R. Malignant solitary fibrous tumor involving the liver. World J Gastroenterol. 2013;19:3354-7.
https://doi.org/10.3748/wjg.v19.i21.3354
9. Nevius DB, Friedman NB. Mesotheliomas and extraovarian thecomas with hypoglycemic and nephrotic syndromes. Cancer. 1959;12:1263-9.
https://doi.org/10.1002/1097-0142(195911/12)12:6<1263::AID-CNCR2820120620>3.0.CO;2-4
10. Ji Y, Fan J, Xu Y, Zhou J, Zeng HY, Tan YS. Solitary fibrous tumor of the liver. Hepatobiliary Pancreat Dis Int. 2006;5:151-3.
11. Terkivatan T, Kliffen M, de Wilt JH, van Geel AN, Eggermont AM, Verhoef C. Giant solitary fibrous tumor of the liver. World J Surg Oncol. 2006;4:81.
https://doi.org/10.1186/1477-7819-4-81
12. Neeff H, Obermaier R, Technau-Ihling K, Werner M, Kurtz C, Imdahl A, et al. Solitary fibrous tumor of the liver: Case report and review of the literature. Langenbecks Arch Surg. 2004;389:293-8.
https://doi.org/10.1007/s00423-004-0488-5
13. Vennarecci G, Ettorre GM, Giovanelli L, del Nonno F, Perracchio L, Visca P, et al. Solitary fibrous tumor of the liver. J Hepatobiliary Pancreat Surg. 2005;12:341-4.
https://doi.org/10.1007/s00534-005-0993-0
14. Perini MV, Herman P, D'Albuquerque LA, Saad WA. Solitary fibrous tumor of the liver: Report of a rare case and review of the literature. Int J Surg. 2008;6:396-9.
https://doi.org/10.1016/j.ijsu.2007.10.004
15. Sun K, Lu JL, Teng XD, Ying LX, Wei JF. Solitary fibrous tumor of the liver: A case report. World J Surg Oncol. 2011;9:37.
https://doi.org/10.1186/1477-7819-9-37
16. Liu Q, Liu J, Chen W, Mao S, Guo Y. Primary solitary fibrous tumors of liver: A case report and literature review. Diagnostic Pathol. 2013;8:195.
https://doi.org/10.1186/1746-1596-8-195
17. Korkolis DP, Apostolaki K, Aggeli C, Plataniotis G, Gontikakis E, Volanaki D, et al. Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report. World J Gastroenterol. 2008;14:6261-4.
https://doi.org/10.3748/wjg.14.6261
18. Fama F, Le Bouc Y, Barrande G, Villeneuve A, Berry MG, Pidoto RR, et al. Solitary fibrous tumor of the liver with IGFII-related hypoglycemia: A case report. Langenbecks Arch Surg. 2008;393:611-6.
https://doi.org/10.1007/s00423-008-0329-z
19. Chithriki M, Jaibaji M, Vandermolen R. Solitary fibrous tumor of the liver with presenting symptoms of hypoglycemic coma. Am Surg. 2004;70:291-3.
20. Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, de Manzoni G, Laterza E, et al. Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia. J Hepatobiliary Pancreat Surg. 1998;5:212-6.
https://doi.org/10.1007/s005340050036
21. Anderson N, Lokich JJ. Mesenchymal tumors associated with hypoglycemia. Cancer. 1979;44:785-90.
https://doi.org/10.1002/1097-0142(197908)44:2<785::AID-CNCR2820440253>3.0.CO;2-S
22. Shetty MR, Boghossian HM, Duffell D, Freel R, González JC. Tumor-induced hypoglycemia. Cancer. 1982;49:1920-3.
https://doi.org/10.1002/1097-0142(19820501)49:9<1920::AID-CNCR2820490927>3.0.CO;2-M
23. Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, et al. Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci. 2000;45:168-74.
https://doi.org/10.1023/A:1005438116772
24. Pen L, Liu Y, Ai Y, Liu Z, He Y, Liu Q. Skull base metastases from a malignant solitary fibrous tumor of the liver: A case report and literature review. Diagnostic Pathol. 2011;6:127.
https://doi.org/10.1186/1746-1596-6-127
25. Fuksbrumer MS, Klimstra D, Panicek DM. Solitary fibrous tumor of the liver: Imaging findings. Am J Radiol. 2000;175:1683-7.
https://doi.org/10.2214/ajr.175.6.1751683
26. Moser T, Nogueira TS, Neuville A, Riehm S, Averous G, Weber JC, et al. Delayed enhancement pattern in a localized fibrous tumor of the liver. Am J Radiol. 2005;184:1578-80.
https://doi.org/10.2214/ajr.184.5.01841578
27. Taboada-Rodríguez V, Zueco-Zueco C, Sobrido-San Pedro C, Martínez-Vicente C. Tumor fibroso solitario hepático: hallazgos radiológicos y revisión de la bibliografía. Radiología. 2010;52:67-70.
https://doi.org/10.1016/j.rx.2009.09.008
28. Soussan M, Felden A, Cyrta J, Morere JF, Douard R, Wind P. Solitary fibrous tumor of the liver. Radiology. 2013;269:304-8.
https://doi.org/10.1148/radiol.13121315
29. Nath DS, Rutzick AD, Sielaff TD. Solitary fibrous tumor of the liver. Am J Radiol. 2006;187:W187-90.
https://doi.org/10.2214/AJR.05.0294
30. Ginat DT, Bokhari A, Bhatt S, Dogra V. Imaging features of solitary fibrous tumors. Am J Radiol. 2011;196:487-95.
https://doi.org/10.2214/AJR.10.4948
31. Weimann A, Ringe B, Klempnauer J, Lamesch P, Gratz KF, Prokop M, et al. Benign liver tumors: Differential diagnosis and indications for surgery. World J Surg. 1997;21:983-91.
https://doi.org/10.1007/s002689900337
32. Terkivatan T, de Wilt JH, de Man RA, van Rijn RR, Zondervan PE, Tilanus HW, et al. Indications and long-term outcome of treatment for benign hepatic tumors. Arch Surg. 2001;136:1033-8.
https://doi.org/10.1001/archsurg.136.9.1033
33. Ibrahim S, Chen CL, Wang SH, Lin CC, Yang CH, Yong CC, et al. Liver resection for benign liver tumors: Indications and outcome. Am J Surg. 2007;193:5-9.
https://doi.org/10.1016/j.amjsurg.2006.04.017
34. Clarke DL, Currie EJ, Madhavan KK, Parks RW, Garden OJ. Hepatic resection for benign non-cystic liver lesions. HPB. 2004;6:115-9.
https://doi.org/10.1080/13651820410026326
35. Novais P, Robles-Medranda C, Pannain VL, Barbosa D, Biccas B, Fogaca H. Solitary fibrous liver tumor: Is surgical approach the best option? J Gastrointest Liver Dis. 2010;19:81-4.
36. Weitz J, Klimstra DS, Cymes K, Jarnagin WR, D'Angelica M, La Quaglia MP, et al. Management of primary liver sarcomas. Cancer. 2007;109:1391-6.
https://doi.org/10.1002/cncr.22530
37. Ali SZ, Hoon V, Hoda S, Heelan R, Zakowski MF. Solitary fibrous tumor: A cytologic-histologic study with clinical, radiologic, and immunohistochemical correlations. Cancer. 1997;81:116-21.
https://doi.org/10.1002/(SICI)1097-0142(19970425)81:2<116::AID-CNCR5>3.0.CO;2-Q
38. Gengler C, Guillou L. Solitary fibrous tumor and hemangiopericytoma: Evolution of a concept. Histopathology. 2006;48:63- 74.
https://doi.org/10.1111/j.1365-2559.2005.02290.x
39. Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S, Hirose T, Sano T. Frequent expression of bcl-2 protein in solitary fibrous tumors. Jpn J Clin Oncol. 1998;28:86-91.
https://doi.org/10.1093/jjco/28.2.86
40. Torabi A, Lele SM, DiMaio D, Pinnt JC, Hess MM, Nelson M, et al. Lack of a common or characteristic cytogenetic anomaly in solitary fibrous tumor. Cancer Genet Cytogenet. 2008;181:60-4.
https://doi.org/10.1016/j.cancergencyto.2007.11.005
41. Levard A, Derbel O, Méeus P, Ranchere D, Ray-Coquard I, Blay JY, et al. Outcome of patients with advanced solitary fibrous tumors: The Center Léon Bérard experience. BMC Cancer. 2013;13:109.
https://doi.org/10.1186/1471-2407-13-109
42. Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, et al. Sunitinib malate and figitumumab in solitary fibrous tumor: Patterns and molecular bases of tumor response. Mol Cancer Ther. 2010;9:1286-97.
https://doi.org/10.1158/1535-7163.MCT-09-1205
43. Stacchiotti S, Negri T, Libertini M, Palassini E, Marrari A, De Troia B, et al. Sunitinib malate in solitary fibrous tumor (SFT). Ann Oncol. 2012;23:3171-9.
https://doi.org/10.1093/annonc/mds143
44. Mosquera JM, Fletcher CD. Expanding the spectrum of malignant progression in solitary fibrous tumors. Am J Surg Pathol. 2009;33:1314-21.
https://doi.org/10.1097/PAS.0b013e3181a6cd33
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2015-01-01
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Beltrán, M. A. Tumor Fibroso Solitario Del hígado: Revisión Del Conocimiento Actual. Rev Colomb Cir 2015, 30, 230-239.
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