Tumor seudopapilar sólido del páncreas
DOI:
https://doi.org/10.30944/20117582.303Palabras clave:
páncreas, neoplasias pancreáticas, diagnóstico, pancreatectomía, laparoscopíaResumen
Los tumores seudopapilares sólidos del páncreas representan del 1 al 2 % de las lesiones neoplásicas del páncreas exocrino. Descritos por primera vez por Frantz, han recibido múltiples denominaciones hasta su clasificación actual por la Organización Mundial de la Salud (OMS). Carecen de un cuadro clínico típico y frecuentemente se diagnostican de manera incidental por estudios de imágenes de sección transversal, en los que se reconocen características clave para su diagnóstico, y se presentan especialmente en mujeres jóvenes y adolescentes. Actualmente, su tratamiento es fundamentalmente quirúrgico, prefiriéndose técnicas conservadoras, con excelentes resultados a largo plazo. Se reporta el caso de una mujer joven con síntomas abdominales inespecíficos, a quien después de tratamientos previos para otras posibles enfermedades, se le practicó una tomografía computarizada de abdomen en la cual se documentó una lesión de características típicas de este tipo de tumor; fue sometida a pancreatectomía distal y esplenectomía laparoscópicas, con confirmación histológica de la neoplasia y sin necesidad de tratamiento adicional posterior
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Referencias bibliográficas
1. Yu PF, Hu ZH, Wang XB, Guo JM, Cheng XD, Zhang YL, et al. Solid pseudopapillary tumor of the pancreas: A review of 553 cases in Chinese literature. World J Gastroenterol. 2010;16:1209-14.
https://doi.org/10.3748/wjg.v16.i10.1209
2. Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT,Raman SP, et al. A systematic review of solid-pseudopapillary neoplasms: Are these rare lesions? Pancreas. 2014;43:331-7.
https://doi.org/10.1097/MPA.0000000000000061
3. Dan D, Rambally R, Cawich SO, Maharaj R, Naraynsingh V. Solid pseudopapillary neoplasms of the pancreas: A report of two cases. Case Rep Med. 2014;14:1-5.
https://doi.org/10.1155/2014/356379
4. Klotz T, Da Ines D, Petitcolin V, Lannareix V, Essamet W, Garcier JM. Solid pseudopapillary neoplasm of the pancreas. Diagn Interv Imaging. 2013;94:1169-74.
https://doi.org/10.1016/j.diii.2013.04.005
5. Romics L, Oláh A, Belágyi T, Hajdú N, Gyürüs P, Ruszinkó V. Solid pseudopapillary neoplasm of the pancreas - proposed algorithms for diagnosis and surgical treatment. Langenbecks Arch Surg. 2010;395:747-55.
https://doi.org/10.1007/s00423-010-0599-0
6. Slako M, Muñoz C, Briceño E, Moisan F, Martínez J, Patillo JC, et al. Tumor sólido pseudopapilar del páncreas: estudio descriptivo de una serie de casos. Rev Chil Cir. 2012;64:251-6.
https://doi.org/10.4067/S0718-40262012000300006
7. Maffuz A, Bustamante FdeT, Silva JA, Torres-Vargas S. Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas. Lancet Oncol. 2005;6:185-6.
https://doi.org/10.1016/S1470-2045(05)01770-5
8. Martin RC, Klimstra DS, Brennan MF, Conlon KC. Solid pseudopapillary tumor of the pancreas: A surgical enigma? Ann Surg Oncol. 2002;9:35-40.
https://doi.org/10.1245/aso.2002.9.1.35
9. Terris B, Cavard C. Diagnosis and molecular aspects of solid pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol. 2014;31:484-90.
https://doi.org/10.1053/j.semdp.2014.08.010
10. Jha BM, Shah P, Agarwal A. Solid pseudopapillary neoplasm of the pancreas mimicking a pseudocyst of pancreas. Med J Armed Forces India. 2015;71:S5-7.
https://doi.org/10.1016/j.mjafi.2012.08.014
11. Machado MC, Machado MA, Bacchella T, Jukemura J, AlmeidaJL, Cunha JE. Solid pseudopapillary neoplasm of the pancreas: Distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery. 2008;143:29-34.
https://doi.org/10.1016/j.surg.2007.07.030
12. Lee SE,Jang JY, Hwang DW, Park KW, Kim SW. Clinical features and outcome of solid pseudopapillary neoplasm: Differences between adults and children. Arch Surg. 2008;143:1218-21.
https://doi.org/10.1001/archsurg.143.12.1218
13. Miglani Ripan K, Nagesh NS, Murthy Divakar S, Shankar BR, Sekhar NR, Ashok Kumar KV. Solid pseudopapillary tumour of pancreas: A rare neoplasm. Indian J Surg. 2010;72:158-60.
https://doi.org/10.1007/s12262-010-0029-0
14. Morales A, Ruíz JM, Estéves HO, Robles-Díaz G, Díaz-Sánchez V. Papillary-cystic neoplasm of the pancreas. A sex-steroid dependent tumor. Int J Pancreatol. 1998;24:219-25.
15. Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, et al. Current diagnosis and management of unusual pancreatic tumors. Am J Surg. 2008;196:100-13.
https://doi.org/10.1016/j.amjsurg.2008.02.005
16. Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in English literature. J Am Coll Surg. 2005;200:965-72.
https://doi.org/10.1016/j.jamcollsurg.2005.02.011
17. Madan AK, Weldon CB, Long WP, Johnson D, Raafat A. Solid and papillary epithelial neoplasm of the pancreas. J Surg Oncol. 2004;85:193-8.
https://doi.org/10.1002/jso.20019
18. Procacci C, Graziani R, Bicego E, Zicari M, Bergamo IA, Zamboni G, et al. Papillary cystic neoplasm of the pancreas: Radiological findings. Abdom Imaging. 1995;20:554-8.
https://doi.org/10.1007/BF01256710
19. Cantisani V, Mortele KJ, Levy A, Glickman JN, Ricci P, Passariello R, et al. MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients. Am J Roentgenol. 2003;18:395-401.
https://doi.org/10.2214/ajr.181.2.1810395
20. Leonher-Ruezga K, López-Espinosa S, Moya A, Pérez J, López R. Tumor seudopapilar sólido del páncreas: presentación de un caso y revisión del tema. Cir Esp. 2015;93:e37-40.
https://doi.org/10.1016/j.ciresp.2013.04.007
21. Sur YK, Lee JH, Kim JK, Park MJ, Kim B, Park MS, et al. Comparison of MR imaging features of solid pseudopapillary neoplasm of pancreas between male and female patients. Eur J Radiol. 2015;84:2065-70.
https://doi.org/10.1016/j.ejrad.2015.07.025
22. Moholkar S, Sebire NJ, Roebuck DJ. Solid-pseudopapillary neoplasm of the pancreas: Radiological-pathological correlation. Pediatr Radiol. 2005;35:819-22.
https://doi.org/10.1007/s00247-005-1461-3
23. Stoita A, Earls P, Williams D. Pancreatic solid pseudopapillary tumours - EUS FNA is the ideal tool for diagnosis. ANZ J Surg. 2010;80:615-8.
https://doi.org/10.1111/j.1445-2197.2010.05404.x
24. Beltrán MA, Arcos J, Hermosilla R, Urbina O, Fuentes T, Andrade P, et al. Tumor sólido pseudopapilar del páncreas en la IV región. Rev Chil Cir. 2015;67:285-91.
https://doi.org/10.4067/S0718-40262015000300008
25. Virgilio E, Mercantini P, Ferri M, Cunsolo G, Tarantino G, Cavallini M, et al. Is EUS-FNA of solid-pseudopapillary neoplasms of the pancreas as a preoperative procedure really necessary and free of acceptable risks? Pancreatology. 2014;14:536-8.
https://doi.org/10.1016/j.pan.2014.08.004
26. Jani N, Dewitt J, Eloubeidi M, Varadarajulu S, Appalaneni V, Hoffman B, et al. Endoscopic ultrasound-guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: A multicenter experience. Endoscopy. 2008;40:200-3.
https://doi.org/10.1055/s-2007-995364
27. Nakeeb AE, Wahab MA, Elkashef WF, Azer M, Kandil T. Solid pseudopapillary tumour of the pancreas: Incidence, prognosis and outcome of surgery (single center experience). Int J Surg. 2013;11:447-57.
https://doi.org/10.1016/j.ijsu.2013.04.009
28. Cienfuegos JA, Lozano MD, Rotellar F, Martí P, Pedano N, Arredondo J, et al. Tumor sólido pseudopapilar del páncreas (TSSP): un enigma sin resolver. Rev Esp Enferm Dig. 2010;102:722-8.
https://doi.org/10.4321/S1130-01082010001200009
29. Kloppel G, Hruban R, Luttges J, Kern S, Klimstra D, Adler G. Solid-pseudopapillary neoplasm. In: World Health Organization Classification of Tumours e Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press; 2000. p. 246-8.
30. Li H, Zhang Y, Du Z, Tang F, Qi X, Yin B, et al. Multi-centric solid-pseudopapillary neoplasm of the pancreas. Med Oncol. 2013;30:330-5.
https://doi.org/10.1007/s12032-012-0330-9
31. De Castro SMM, Singhal D,Aronson DC, Busch OR, van Gulik TM, Obertop H, et al. Management of solid pseudopapillary neoplasms of the pancreas: A comparison with standard pancreatic neoplasms. World J Surg. 2007;31:1129-34.
https://doi.org/10.1007/s00268-006-0214-2
32. Chang H, Gong Y, Xu J, Su Z, Qin C, Zhang Z. Clinical strategy for the management of solid pseudopapillary tumor of the pancreas: Aggressive or less? Int J Med Sci. 2010;7:309-13.
https://doi.org/10.7150/ijms.7.309
33. Frago R, Fabregat R, Jorba R, García-Borobia F, Altet J, Serrano MT, et al. Tumor sólido pseudopapilar de páncreas: diagnóstico y tratamiento curativo. Rev Esp Enferm Dig. 2006;98:809-16.
https://doi.org/10.4321/S1130-01082006001100002
34. Tajima Y, Kohara N, Maeda J, Inoue K, Kitasato A, Natsuda K, et al. Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: Report of a case. Surg Today. 2012;42:776-80.
https://doi.org/10.1007/s00595-012-0208-7
35. De Rooij T, Jilesen AP, Boerma D, Bonsing BA, Bosscha K, van Dam RM, et al. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease. J Am Coll Surg. 2015;220:263-70.
https://doi.org/10.1016/j.jamcollsurg.2014.11.010
36. Ricci C, Casadei R, Lazzarini E, D'Ambra M, Buscemi S, Pacilio CA, et al. Laparoscopic distal pancreatectomy in Italy: A systematic review and meta-analysis. Hepatob Pancreat Dis. 2014;13:458-63.
https://doi.org/10.1016/S1499-3872(14)60297-6
37. Kudsi OY, Gagner M, Jones DB. Laparoscopic distal pancreatectomy. Surg Oncol Clin North Am. 2013;22:59-73.
https://doi.org/10.1016/j.soc.2012.08.003
38. Sperlongano P, Esposito E, Esposito A, Clarizia G, Moccia G, Malinconico FA, et al. Laparoscopic pancreatectomy: Did the indications change? A review from literature. Int J Surg. 2015;21(Suppl.1):S22-5.
https://doi.org/10.1016/j.ijsu.2015.04.094
39. Mohkam K, Farges O, Pruvot FR, Muscari F, Regimbeau JM, Regenet N, et al. Toward a standard technique for laparoscopic distal pancreatectomy? Synthesis of the 2013 ACHBT Spring workshop. J Visc Surg . 2015;152:167-78.
https://doi.org/10.1016/j.jviscsurg.2015.04.002
40. Guo N, Zhou QB, Chen RF, Zou SQ, Li ZH, Lin Q, et al. Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: Analysis of 24 cases. Can J Surg. 2011;54:368-74.
https://doi.org/10.1503/cjs.011810
https://doi.org/10.3748/wjg.v16.i10.1209
2. Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT,Raman SP, et al. A systematic review of solid-pseudopapillary neoplasms: Are these rare lesions? Pancreas. 2014;43:331-7.
https://doi.org/10.1097/MPA.0000000000000061
3. Dan D, Rambally R, Cawich SO, Maharaj R, Naraynsingh V. Solid pseudopapillary neoplasms of the pancreas: A report of two cases. Case Rep Med. 2014;14:1-5.
https://doi.org/10.1155/2014/356379
4. Klotz T, Da Ines D, Petitcolin V, Lannareix V, Essamet W, Garcier JM. Solid pseudopapillary neoplasm of the pancreas. Diagn Interv Imaging. 2013;94:1169-74.
https://doi.org/10.1016/j.diii.2013.04.005
5. Romics L, Oláh A, Belágyi T, Hajdú N, Gyürüs P, Ruszinkó V. Solid pseudopapillary neoplasm of the pancreas - proposed algorithms for diagnosis and surgical treatment. Langenbecks Arch Surg. 2010;395:747-55.
https://doi.org/10.1007/s00423-010-0599-0
6. Slako M, Muñoz C, Briceño E, Moisan F, Martínez J, Patillo JC, et al. Tumor sólido pseudopapilar del páncreas: estudio descriptivo de una serie de casos. Rev Chil Cir. 2012;64:251-6.
https://doi.org/10.4067/S0718-40262012000300006
7. Maffuz A, Bustamante FdeT, Silva JA, Torres-Vargas S. Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas. Lancet Oncol. 2005;6:185-6.
https://doi.org/10.1016/S1470-2045(05)01770-5
8. Martin RC, Klimstra DS, Brennan MF, Conlon KC. Solid pseudopapillary tumor of the pancreas: A surgical enigma? Ann Surg Oncol. 2002;9:35-40.
https://doi.org/10.1245/aso.2002.9.1.35
9. Terris B, Cavard C. Diagnosis and molecular aspects of solid pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol. 2014;31:484-90.
https://doi.org/10.1053/j.semdp.2014.08.010
10. Jha BM, Shah P, Agarwal A. Solid pseudopapillary neoplasm of the pancreas mimicking a pseudocyst of pancreas. Med J Armed Forces India. 2015;71:S5-7.
https://doi.org/10.1016/j.mjafi.2012.08.014
11. Machado MC, Machado MA, Bacchella T, Jukemura J, AlmeidaJL, Cunha JE. Solid pseudopapillary neoplasm of the pancreas: Distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery. 2008;143:29-34.
https://doi.org/10.1016/j.surg.2007.07.030
12. Lee SE,Jang JY, Hwang DW, Park KW, Kim SW. Clinical features and outcome of solid pseudopapillary neoplasm: Differences between adults and children. Arch Surg. 2008;143:1218-21.
https://doi.org/10.1001/archsurg.143.12.1218
13. Miglani Ripan K, Nagesh NS, Murthy Divakar S, Shankar BR, Sekhar NR, Ashok Kumar KV. Solid pseudopapillary tumour of pancreas: A rare neoplasm. Indian J Surg. 2010;72:158-60.
https://doi.org/10.1007/s12262-010-0029-0
14. Morales A, Ruíz JM, Estéves HO, Robles-Díaz G, Díaz-Sánchez V. Papillary-cystic neoplasm of the pancreas. A sex-steroid dependent tumor. Int J Pancreatol. 1998;24:219-25.
15. Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, et al. Current diagnosis and management of unusual pancreatic tumors. Am J Surg. 2008;196:100-13.
https://doi.org/10.1016/j.amjsurg.2008.02.005
16. Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in English literature. J Am Coll Surg. 2005;200:965-72.
https://doi.org/10.1016/j.jamcollsurg.2005.02.011
17. Madan AK, Weldon CB, Long WP, Johnson D, Raafat A. Solid and papillary epithelial neoplasm of the pancreas. J Surg Oncol. 2004;85:193-8.
https://doi.org/10.1002/jso.20019
18. Procacci C, Graziani R, Bicego E, Zicari M, Bergamo IA, Zamboni G, et al. Papillary cystic neoplasm of the pancreas: Radiological findings. Abdom Imaging. 1995;20:554-8.
https://doi.org/10.1007/BF01256710
19. Cantisani V, Mortele KJ, Levy A, Glickman JN, Ricci P, Passariello R, et al. MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients. Am J Roentgenol. 2003;18:395-401.
https://doi.org/10.2214/ajr.181.2.1810395
20. Leonher-Ruezga K, López-Espinosa S, Moya A, Pérez J, López R. Tumor seudopapilar sólido del páncreas: presentación de un caso y revisión del tema. Cir Esp. 2015;93:e37-40.
https://doi.org/10.1016/j.ciresp.2013.04.007
21. Sur YK, Lee JH, Kim JK, Park MJ, Kim B, Park MS, et al. Comparison of MR imaging features of solid pseudopapillary neoplasm of pancreas between male and female patients. Eur J Radiol. 2015;84:2065-70.
https://doi.org/10.1016/j.ejrad.2015.07.025
22. Moholkar S, Sebire NJ, Roebuck DJ. Solid-pseudopapillary neoplasm of the pancreas: Radiological-pathological correlation. Pediatr Radiol. 2005;35:819-22.
https://doi.org/10.1007/s00247-005-1461-3
23. Stoita A, Earls P, Williams D. Pancreatic solid pseudopapillary tumours - EUS FNA is the ideal tool for diagnosis. ANZ J Surg. 2010;80:615-8.
https://doi.org/10.1111/j.1445-2197.2010.05404.x
24. Beltrán MA, Arcos J, Hermosilla R, Urbina O, Fuentes T, Andrade P, et al. Tumor sólido pseudopapilar del páncreas en la IV región. Rev Chil Cir. 2015;67:285-91.
https://doi.org/10.4067/S0718-40262015000300008
25. Virgilio E, Mercantini P, Ferri M, Cunsolo G, Tarantino G, Cavallini M, et al. Is EUS-FNA of solid-pseudopapillary neoplasms of the pancreas as a preoperative procedure really necessary and free of acceptable risks? Pancreatology. 2014;14:536-8.
https://doi.org/10.1016/j.pan.2014.08.004
26. Jani N, Dewitt J, Eloubeidi M, Varadarajulu S, Appalaneni V, Hoffman B, et al. Endoscopic ultrasound-guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: A multicenter experience. Endoscopy. 2008;40:200-3.
https://doi.org/10.1055/s-2007-995364
27. Nakeeb AE, Wahab MA, Elkashef WF, Azer M, Kandil T. Solid pseudopapillary tumour of the pancreas: Incidence, prognosis and outcome of surgery (single center experience). Int J Surg. 2013;11:447-57.
https://doi.org/10.1016/j.ijsu.2013.04.009
28. Cienfuegos JA, Lozano MD, Rotellar F, Martí P, Pedano N, Arredondo J, et al. Tumor sólido pseudopapilar del páncreas (TSSP): un enigma sin resolver. Rev Esp Enferm Dig. 2010;102:722-8.
https://doi.org/10.4321/S1130-01082010001200009
29. Kloppel G, Hruban R, Luttges J, Kern S, Klimstra D, Adler G. Solid-pseudopapillary neoplasm. In: World Health Organization Classification of Tumours e Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press; 2000. p. 246-8.
30. Li H, Zhang Y, Du Z, Tang F, Qi X, Yin B, et al. Multi-centric solid-pseudopapillary neoplasm of the pancreas. Med Oncol. 2013;30:330-5.
https://doi.org/10.1007/s12032-012-0330-9
31. De Castro SMM, Singhal D,Aronson DC, Busch OR, van Gulik TM, Obertop H, et al. Management of solid pseudopapillary neoplasms of the pancreas: A comparison with standard pancreatic neoplasms. World J Surg. 2007;31:1129-34.
https://doi.org/10.1007/s00268-006-0214-2
32. Chang H, Gong Y, Xu J, Su Z, Qin C, Zhang Z. Clinical strategy for the management of solid pseudopapillary tumor of the pancreas: Aggressive or less? Int J Med Sci. 2010;7:309-13.
https://doi.org/10.7150/ijms.7.309
33. Frago R, Fabregat R, Jorba R, García-Borobia F, Altet J, Serrano MT, et al. Tumor sólido pseudopapilar de páncreas: diagnóstico y tratamiento curativo. Rev Esp Enferm Dig. 2006;98:809-16.
https://doi.org/10.4321/S1130-01082006001100002
34. Tajima Y, Kohara N, Maeda J, Inoue K, Kitasato A, Natsuda K, et al. Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: Report of a case. Surg Today. 2012;42:776-80.
https://doi.org/10.1007/s00595-012-0208-7
35. De Rooij T, Jilesen AP, Boerma D, Bonsing BA, Bosscha K, van Dam RM, et al. A nationwide comparison of laparoscopic and open distal pancreatectomy for benign and malignant disease. J Am Coll Surg. 2015;220:263-70.
https://doi.org/10.1016/j.jamcollsurg.2014.11.010
36. Ricci C, Casadei R, Lazzarini E, D'Ambra M, Buscemi S, Pacilio CA, et al. Laparoscopic distal pancreatectomy in Italy: A systematic review and meta-analysis. Hepatob Pancreat Dis. 2014;13:458-63.
https://doi.org/10.1016/S1499-3872(14)60297-6
37. Kudsi OY, Gagner M, Jones DB. Laparoscopic distal pancreatectomy. Surg Oncol Clin North Am. 2013;22:59-73.
https://doi.org/10.1016/j.soc.2012.08.003
38. Sperlongano P, Esposito E, Esposito A, Clarizia G, Moccia G, Malinconico FA, et al. Laparoscopic pancreatectomy: Did the indications change? A review from literature. Int J Surg. 2015;21(Suppl.1):S22-5.
https://doi.org/10.1016/j.ijsu.2015.04.094
39. Mohkam K, Farges O, Pruvot FR, Muscari F, Regimbeau JM, Regenet N, et al. Toward a standard technique for laparoscopic distal pancreatectomy? Synthesis of the 2013 ACHBT Spring workshop. J Visc Surg . 2015;152:167-78.
https://doi.org/10.1016/j.jviscsurg.2015.04.002
40. Guo N, Zhou QB, Chen RF, Zou SQ, Li ZH, Lin Q, et al. Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: Analysis of 24 cases. Can J Surg. 2011;54:368-74.
https://doi.org/10.1503/cjs.011810
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2016-12-01
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Higuita, A. M. .; Correa, . J. L.; Becerra, . L. F.; Vanegas, L. F. . Tumor Seudopapilar sólido Del páncreas. Rev Colomb Cir 2016, 31, 289-295.
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