Rabdomiosarcoma retroperitoneal en el adulto
Palabras clave:
rabdomiosarcoma, neoplasias retroperitoneales, procedimientos quirúrgicos operativos, quimioterapia, radioterapiaResumen
El rabdomiosarcoma es un tumor maligno de los tejidos blandos que representa, aproximadamente, 4 a 8 % de los tumores sólidos en los niños. Generalmente, se origina en la cabeza y el cuello, y el sistema genitourinario. El rabdomiosarcoma retroperitoneal rara vez se ha reportado en la literatura científica, y el rabdomiosarcoma embrionario de origen epiploico en los adultos es aún más raro.
Este tumor maligno de tejidos blandos es más común en los niños. El número de casos por millón de habitantes entre 1994 y 2005, fue de 8,3 (hombres) y 3,7 (mujeres); la mayoría de los casos son esporádicos.
Según el tipo histológico, son tumores embrionarios, alveolares o pleomórficos. El rabdomiosarcoma embrionario se llama así por su parecido con el músculo esquelético inmaduro y representa el 60 % de los casos de este tumor en los pacientes menores de 20 años de edad.
El propósito de este artículo fue revisar la literatura científica y presentar un caso clínico de rabdomiosarcoma retroperitoneal en un paciente adulto de la Clínica Universitaria Colombia.
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Referencias bibliográficas
https://doi.org/10.1200/JCO.2008.19.7483
2. Ferrari A, Dileo P, Casanova M, Bertulli R, Meazza C, Gandola L. Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer. 2003;98:571-80.
https://doi.org/10.1002/cncr.11550
3. Raney RB, Maurer HM, Anderson JR, Andrassy R, Donaldson S, Qualman S, et al. The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major lessons from the IRS-I through IRS-IV studies as background for the current IRS-V treatment protocols. Sarcoma. 2001;5:9-15.
https://doi.org/10.1080/13577140120048890
4. Hawkins WG, Hoos A, Antonescu CR, Claus F, Urist MJ, Leung DH. Clinicopathologic analysis of patients with adult rhabdomyosarcoma. Cancer. 2001;91:794-803.
https://doi.org/10.1002/1097-0142(20010215)91:4<794::AID-CNCR1066>3.0.CO;2-Q
5. Colleoni M, Nelli P, Sgarbossa G, Scatena C, Massi D, Franchi A, De Paoli A. Primary cutaneous rhabdomyosarcoma in adults: Description of an uncommon aggressive disease. Acta Oncol. 1996;35:494-5.
https://doi.org/10.3109/02841869609109930
6. Gaffney EF, Dervan PA, Fletcher CD. Pleomorphic rhabdomyo- sarcoma in adulthood: Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol. 1993;17:601-9.
https://doi.org/10.1097/00000478-199306000-00008
7. Kattan J, Culine S, Terrier-Lacombe MJ, Jae Y, Mahul A, Kyu-Rae K. Paratesticular rhabdomyosarcoma in adult patients: 16-year experience at Institut Gustave-Roussy. Ann Oncol. 1993;4:871-5.
https://doi.org/10.1093/oxfordjournals.annonc.a058396
8. Esnaola NF, Rubin BP, Baldini EH, Cuneyt U, Hakan B, Okan K. Response to chemotherapy and predictors of survival in adult rhabdomyosarcoma. Ann Surg. 2001;234:215-23.
https://doi.org/10.1097/00000658-200108000-00012
9. Seidal T, Kindblom LG, Angervall L. Rhabdomyosarcoma in middle-aged and elderly individuals. APMIS. 1989;97:236-48.
https://doi.org/10.1111/j.1699-0463.1989.tb00783.x
10. La Quaglia MP, Heller G, Ghavimi F, Narayan H, Swaminathan R, Arun K, Ashok S. The effect of age at diagnosis on outcome in rhabdomyosarcoma. Cancer. 1994;73:109-17.
https://doi.org/10.1002/1097-0142(19940101)73:1<109::AID-CNCR2820730120>3.0.CO;2-S
11. Little DJ, Ballo MT, Zagars G, Pisters P, Patel S, El-Naggar A. Adult rhabdomyosarcoma: Outcome following multimodality treatment. Cancer. 2002;95:377-88.
https://doi.org/10.1002/cncr.10669
12. Hassan I, Park SZ, Donohue JH, Erzen D, Sencar M, Novak J. Operative management of primary retroperitoneal sarco- mas: a reappraisal of an institutional experience. Ann Surg. 2004;239:244-50.
https://doi.org/10.1097/01.sla.0000108670.31446.54
13. Sepúlveda L, Tordecilla J, Becker A, Raney B, Anderson J, Barr F. Resultados por protocolos del PINDA. Sarcoma de partes blandas. En: Ministerio de Salud. Cáncer Infantil en Chile. Santiago de Chile: Ministerio de Salud; 2000. p. 194-208.
14. Fernando Val-Bernal J, Fernández N, Gómez-Román JJ. Spindle cell rhabdomyosarcoma in adults: A case report and literature review. Pathol Res Pract. 2000;196:67-72.
https://doi.org/10.1016/S0344-0338(00)80024-2
15. Joshi D, Anderson JR, Paidas C, Ferrari A, Dileo P, Casanova M. Age is an independent prognostic factor in rhabdomyosarcoma: A report from the Soft Tissue Sarcoma Committee of the Chil- dren's Oncology Group. Pediatr Blood Cancer. 2004;42:64-73.
https://doi.org/10.1002/pbc.10441
16. National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program Public - Use Data (1973-2005). National Cancer Institute, DCCPS, Surveillance Research Pro- gram, Cancer Statistics Branch, released April 2008, based on the November 2007 submission. Fecha de consulta: 1° de mayo de 2011. Disponible en: http://www .seer.cancer.gov.
17. Meza JL, Anderson J, Pappo AS, Smith A, Harris M, Meyer J. Analysis of prognostic factors in patients with non-metastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: The Children's Oncology Group. J Clin Oncol. 2006;24:3844-51.
https://doi.org/10.1200/JCO.2005.05.3801
18. Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C, Thomas JM. Surgical management of primary and recurrent retroperi- toneal liposarcoma. Br J Surg. 2005;92:246-52.
https://doi.org/10.1002/bjs.4802
19. Anaya DA, Lahat G, Liu J, Lazar AJ, Tuvin D, Hajoibashi S. Multifocality in retroperitoneal sarcoma: a prognostic factor critical to surgical decision-making. Ann Surg. 2008;23:117-26.
20. Punyko JA, Mertens AC, Baker KS, Int-Veen C, Winkler P, Leuschner I, Schuck A, Schmidt BF, Lochbuehler H. Long- term survival probabilities for childhood rhabdomyosarcoma: A population based evaluation. Cancer. 2005;103:1475-83.
https://doi.org/10.1002/cncr.20929
21. Komdeur R, Klunder J, Graaf WT, Berg E, de Bont E. Multidrug resistance proteins in rhabdomyosarcomas: Comparison between children and adults. Cancer. 2003;97:1999-2005.
https://doi.org/10.1002/cncr.11259
22. Ballo MT, Zagars GK, Pollock RE, Benjamin RS, Feig BW, Cormier JN, et al. Retroperitoneal soft tissue sarcoma: An analysis of radiation and surgical treatment. Int J Radiat Oncol Biol Phys. 2007;67:158-63.
https://doi.org/10.1016/j.ijrobp.2006.08.025
23. Brennan MF. Retroperitoneal sarcoma: Time for a national trial. Ann Surg Oncol. 2002;9:324-5.
https://doi.org/10.1007/BF02573865
24. Caudle AS, Tepper JE, Calvo BF, Meyers MO, Goyal LK, Cance WG, Kim HJ. Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas. Ann Surg Oncol. 2007;14:577-82.
https://doi.org/10.1245/s10434-006-9248-9
25. Chen C, Yin L, Peng CH, Cai Y, Li Y, Zhao R, Zhou H, Li H. Prognostic factors of retroperitoneal sarcomas: Analysis of 132 cases. Chin Med J. 2007;120:1047-50.
https://doi.org/10.1097/00029330-200706020-00004
26. Chiche L, Mongredien B, Brocheriou I, Kieffer E. Primary tumors of the thoracoabdominal aorta: Surgical treatment of 5 patients and review of the literature. Ann Vasc Surg. 2003;17:354-64.
https://doi.org/10.1007/s10016-003-0018-x
27. Goset K, Córdova A, Varas M, Badínez L. Tratamiento actual del rabdomiosarcoma pediátrico en Chile. Presentación de 2 casos clínicos. Rev Chil Pediatr. 2002;73:375-9.
https://doi.org/10.4067/S0370-41062002000400007
28. Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 1993;363:640-4.
https://doi.org/10.1038/363640a0
29. Ferrario T , Karakousis CP . Retroperitoneal sarcomas: Grade and survival. Arch Surg. 2003;138:248-51.
https://doi.org/10.1001/archsurg.138.3.248
30. Dzsinich C, Gloviczki P, van Heerden JA. Primary venous leiomyosarcoma: A rare but lethal disease. J Vasc Surg. 1992;15:592-603.
https://doi.org/10.1016/0741-5214(92)90003-Q
31. Erzen D, Sencar M, Novak J. Retroperitoneal sarcoma: 25 years of experience with aggressive surgical treatment at the Institute of Oncology, Ljubljana. J Surg Oncol. 2005;91:1-9.
https://doi.org/10.1002/jso.20265
32. O'Neill JA Jr, Grosfeld JL, Fonkalsrud EW, Coran AG, Calda- mone AA, Rhabdomyosarcoma. Principles of Pediatric Surgery. St. Louis, MO 2003, Mosby, Pp. 229-238.
33. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin. 2007;57:43-66.
https://doi.org/10.3322/canjclin.57.1.43
34. Kotilingam D, Lev DC, Lazar AJ, Pollock RE. Staging soft tissue sarcoma: Evolution and change. CA Cancer J Clin. 2006;56:282-91.
https://doi.org/10.3322/canjclin.56.5.282
35. Windham TC, Pisters PW. Retroperitoneal sarcomas. Cancer Control. 2005;12:36-43.
https://doi.org/10.1177/107327480501200105
36. Mendenhall WM, Zlotecki RA, Hochwald SN, Hassan I, Park SZ, Donohue JH. Retroperitoneal soft tissue sarcoma. Cancer. 2005;104:669-75.
https://doi.org/10.1002/cncr.21264
37. Katz MH, Choi EA, Pollock RE. Current concepts in multimodal- ity therapy for retroperitoneal sarcoma. Expert Rev Anticancer Ther. 2007;7:159-68.
https://doi.org/10.1586/14737140.7.2.159
38. Raut CP, Pisters PW. Retroperitoneal sarcomas: Combined modality treatment approaches. J Surg Oncol. 2006;94:81-7.
https://doi.org/10.1002/jso.20543
39. Evans HL. Atypical lipomatous tumor, its variants, and its com- bined forms: A study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol. 2007;31:1-14.
https://doi.org/10.1097/01.pas.0000213406.95440.7a
40. Pisters PW, Leung DH, Woodruff J, Pisters M, Harrison L, Leung, D. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol. 1996;14:1679-89.
https://doi.org/10.1200/JCO.1996.14.5.1679
41. Brennan MF. Staging of soft tissue sarcomas. Ann Surg Oncol. 1999;6:8-9.
https://doi.org/10.1007/s10434-999-0008-5
42. Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and fol- lowed at a single institution. Ann Surg. 1998;228:355-65.
https://doi.org/10.1097/00000658-199809000-00008
43. Gronchi A, Casali PG, Fiore M, Lewis JJ, Leung D, Woodruff JM. Retroperitoneal soft tissue sarcomas: Patterns of recur- rence in 167 patients treated at a single institution. Cancer. 2004;100:2448-55.
https://doi.org/10.1002/cncr.20269
44. Stoeckle E, Coindre JM, Bonvalot S, Kantor G, Terrier P, Bonichon F. Prognostic factors in retroperitoneal sarcoma: a mul- tivariate analysis of a series of 165 patients of the French Cancer Center Federation Sarcoma Group. Cancer. 2001;92:359-68.
https://doi.org/10.1002/1097-0142(20010715)92:2<359::AID-CNCR1331>3.0.CO;2-Y
45. Lahat G, Anaya DA, Wang X, Madewell E, Qiao W, Tuvin D. Resectable well-differentiated versus dedifferentiated lipo- sarcomas: Two different diseases possibly requiring different treatment approaches. Ann Surg Oncol. 2008;15:1585-93.
https://doi.org/10.1245/s10434-007-9805-x
46. Mejía O, Castro de Pabón E, Barbosa G. Sarcoma alveolar de partes blandas: reporte de caso y casuística en el Instituto Nacional de Cancerología, Colombia. Revista Colombiana de Cancerología. 2003;7:25-32.
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