Utilización de la citrulina plasmática como marcador de la función intestinal: aplicaciones en trasplante de intestino y otras enfermedades digestivas

Autores/as

  • Luciana Teixeira De Siqueira Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.
  • Álvaro Antônio Bandeira Ferraz Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.
  • Josemberg Marins Campos Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.
  • Edmundo Machado Ferraz Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.
  • Manoel Galvão Neto Gastro-Obeso Center, São Paulo, Brasil.
  • Natan Zundel Florida International University, USA.

Palabras clave:

citrulina, glutamina, intestino delgado, trasplante, síndrome de intestino corto

Resumen

El intestino delgado es responsable, no sólo de la digestión y la absorción de los nutrientes, sino también del metabolismo de varios aminoácidos, entre ellos, la glutamina, principal precursor de la citrulina plasmática.

El metabolismo único de la citrulina ha atraído interés científico en la aplicación clínica como marcador de la función intestinal en algunas enfermedades y en procedimientos quirúrgicos como el trasplante de intestino delgado y en resecciones intestinales extensas, que desencadenan el síndrome de intestino corto. Se han propuesto diversos marcadores para la valoración de la función intestinal pero, ante la baja sensibilidad y especificidad, además de la difícil aplicación clínica, la citrulina viene mostrándose como una herramienta no invasiva de la valoración de la masa y funcionalidad de los enterocitos. El objetivo de esta revisión es describir la importancia de la citrulina en las principales enfermedades y procedimientos quirúrgicos del intestino delgado, destacando su metabolismo, aplicaciones en el trasplante de intestino y perspectivas de su aplicación clínica en otras enfermedades digestivas.

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Biografía del autor/a

Luciana Teixeira De Siqueira, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Departamento de Cirugía, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Álvaro Antônio Bandeira Ferraz, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Departamento de Cirugía, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Josemberg Marins Campos, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Departamento de Cirugía, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Edmundo Machado Ferraz, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Departamento de Cirugía, Servicio de Cirugía General del Hospital de las Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.

Manoel Galvão Neto, Gastro-Obeso Center, São Paulo, Brasil.

Gastro-Obeso Center, São Paulo, Brasil.

Natan Zundel, Florida International University, USA.

Fundación Santa Fe de Bogotá, Colombia; Florida International University, USA.

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2009-12-20

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(1)
De Siqueira, L. T.; Bandeira Ferraz, Álvaro A.; Marins Campos, J.; Machado Ferraz, E.; Galvão Neto, M.; Zundel, N. Utilización De La Citrulina plasmática Como Marcador De La función Intestinal: Aplicaciones En Trasplante De Intestino Y Otras Enfermedades Digestivas. Rev Colomb Cir 2009, 24, 258-268.

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